19.
Biomimetic Vesicles with Designer Phospholipids Can Sense Environmental Redox Cues
Erguven, H., Wang, L., Gutierrez, B., Izgu, E. C.*
ChemRxiv 2023, doi: 10.26434/chemrxiv-2023-p0nwc
18.
Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules
Hast, K., Stone, M. R. L., Jia, Z., Baci, M., Aggarwal, T., Izgu, E. C.*
ACS Applied Materials & Interfaces 2023,15, 4996–5009. (Link) | bioRxiv 2022, doi: 10.1101/2021.10.01.462811
17.
Phosphatidic Acid Mediates the Nem1-Spo7/Pah1 Phosphatase Cascade in Yeast Lipid Synthesis
Kwiatek, J. M., Gutierrez, B., Izgu, E. C., Han, G-S., Carman, G. M.
Journal of Lipid Research 2022, 63, 100282. (link)
16.
Activity-Based Imaging of Lipid Environments Targeted by Peroxynitrite in Biomimetic Vesicles and Live Cells
Gutierrez, B., Erguven, H., Stone, M. R. L., Aggarwal, T., Izgu, E. C.*
BioRxiv 2022, doi: 10.1101/2022.06.22.497268
Giant vesicle
15.
MicroRNA Detection in Biologically Relevant Media Using a Split Aptamer Platform
Wang, L., Hast, K., Aggarwal, T., Baci, M., Hong, J., Izgu, E. C.*
Bioorganic & Medicinal Chemistry 2022, 69, 116909. (Link) | bioRxiv 2022, doi: 10.1101/2022.01.17.476684
Special issue honoring Neal Devaraj: Chemical Tools for Interrogating Biological Processes
14.
Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign
Aggarwal, T., Hansen, A. W., Hong, J., Ganguly, A., York, D. M., Khare, S. D.*, Izgu, E. C.*
ACS Chemical Biology 2022, 17, 1924–1936. (Link) | BioRxiv 2021, doi: 10.1101/2021.12.28.474375
13.
Catecholamine-Copper Redox as a Basis for Site-Specific Single-Step Functionalization of Material Surfaces
Jia, Z., Hast, K., Izgu, E. C.*
ACS Applied Materials & Interfaces 2021, 13, 4711–4722. (Link)
12.
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression
Yildirim, O., Izgu, E. C., Damle, M., Chalei, V., Ji, F., Sadreyev, R. I., Szostak, J. W., Kingston, R. E.
Cell Reports 2020, 31, 107629. (Link)
WT RPE1 cells
Early S phase block: Impact on chromosome organization, cell cycle, and nuclear division.
S phase retardation: Impact on gene expression, protein localization, and intracellular transport.
Publications Prior to Research as Principal Investigator
11.
DNA Polymerase Activity on Synthetic N3′→P5′ Phosphoramidate DNA Templates
Lelyveld, V. S., O’Flaherty, D. K., Zhou, L., Izgu, E. C., Szostak, J. W.
Nucleic Acids Research 2019, 47, 8941–8949. (Link)
10.
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole-Activated Nucleotides
Li, L., Prywes, N., Tam, C. P., O’Flaherty, D. K., Lelyveld, V. S., Izgu, E. C., Pal, A., Szostak, J. W.
Journal of the American Chemical Society 2017, 139, 1810–1813. (Link)
9.
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes
Tam, C. P., Fahrenbach, A. C., Björkbom, A., Prywes, N., Izgu, E. C., Szostak, J. W.
Journal of the American Chemical Society 2017, 139, 571–574. (Link)
8.
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane
Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z., Szostak, J. W.
Journal of the American Chemical Society 2016, 138, 16669–16676. (Link)
7.
Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Nonenzymatic Copying of Nucleic Acid Templates
Izgu, E. C., Oh, S. S., Szostak, J. W.
Chemical Communications 2016, 52, 3684–3686. (Link)
6.
Uncovering the Thermodynamics of Monomer Binding for RNA Replication
Izgu, E. C.,* Fahrenbach, A. C.,* Zhang, N., Li L., Zhang, W.; Blain, C., Larsen, A. T., Szostak, J. W.
Journal of the American Chemical Society 2015, 137, 6373–6382. (Link)
5.
Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group
Izgu, E. C., Hoye, T. R.
Chemical Science 2013, 4, 2262–2266. (Link)
-
Highlighted by Ebner, C. & Carreira, E. M. in Synfacts 2013, 9, 0589.
4.
o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the
2-Aminophenyl Substituent
Izgu, E. C., Hoye, T. R.
Tetrahedron Letters 2012, 53, 4938–4941. (Link)
3.
Access to Functionalized Steroid Side Chains via Modified Julia Olefination
Izgu, E. C., Burns, A. C., Hoye, T. R.
Organic Letters 2011, 13, 703–705. (Link)
2.
1
Long-range Shielding Effects in the H NMR Spectra of Mosher-like Ester Derivatives
Hoye, T. R., Erickson, S. E., Erickson-Birkedahl, S. L., Hale, C. R. H., Izgu, E. C., Mayer, M. J., Notz, P. K., Renner, M. K.
Organic Letters 2010, 12, 1768–1771. (Link)
1.
Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands
Bulut, A., Aslan, A., Izgu, E. C., Dogan, O.
Tetrahedron: Asymmetry 2007, 18, 1013–1016. (Link)
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