25.
cGAS–STING Pathway in Lung Cancer and Emerging Therapeutic Approaches
Joshi A., Izgu E. C.*
Drug Discovery Today
(in press)
24.
Imaging Oxidative and Nitrative Stress in Membranes
Wang L.,§, Izgu E. C.§*
(§ Equal contribution)
Methods in Enzymology 2025, Vol. 726, 114–142 (Link)
Lipids and Membranes: Detection by Imaging and Lipidomics
23.
Benzylic Trifluoromethyl Accelerates 1,6-Elimination Toward Rapid Probe Activation
Wang L., Sivakumar A., Zhang R.,§ Cho S.,§
Aggarwal T., Kim Y., Wang L., Izgu E. C.*
(§ Equal contribution)
bioRxiv 2024 (Link)
22.
A Small-Molecule Approach Enables RNA Aptamers to Function as Sensors for Reactive Inorganic Targets
Aggarwal T.,§ Wang L.,§ Gutierrez B., Guven H., Erguven H., Cho S., Izgu E. C.*
Angewandte Chemie International Edition 2025, 64, e202421936 (Link), Designated as Hot Paper
Highlighted in Chemistry & Engineering News (C&EN)
Highlighted in EurekAlert!
21.
Protocol for Detecting Nitrative Stress in Biological Lipid Membranes in Murine Cells and Tissues
Aggarwal T., Bellomo A.,§ Stevenson E. R.,§
Herbert J., Laskin D. L., Gow A. J., Izgu E. C.*
(§ Equal contribution)
STAR Protocols 2024, 5, 103268 (Link)
20.
Protocol for Building Synthetic Protocell Membranes that Sense Redox Using Synthetic Phospholipids and Natural Lipids
Wang L.,§ Dresel M. J.,§ Robinson M., Izgu E. C.*
(§ Equal contribution)
STAR Protocols 2024, 5, 103169 (Link)
19.
Biomimetic Vesicles with Designer Phospholipids Can Sense Environmental Redox Cues
Erguven H.,§ Wang L.,§ Gutierrez B., Beaven A. H., Sodt A. J., Izgu E. C.*
(§ Equal contribution)
JACS Au 2024, 4, 1841–1853. (Link)
ChemRxiv 2023
18.
Direct Assessment of Nitrative Stress in Lipid Environments: Applications of a Designer Lipid-Based Biosensor for Peroxynitrite
Gutierrez B.,§ Aggarwal T.,§ Erguven H., Stone M. R. L., Guo C., Bellomo A., Abramova E., Stevenson E., Laskin D. L., Gow A. J., Izgu E. C.*
(§ Equal contribution)
iScience 2023, 26, 108567. (Link)
17.
Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules
Hast K., Stone M. R. L., Jia Z., Baci M., Aggarwal T., Izgu E. C.*
ACS Applied Materials & Interfaces 2023,15, 4996–5009. (Link)
bioRxiv 2022
16.
Phosphatidic Acid Mediates the Nem1-Spo7/Pah1 Phosphatase Cascade in Yeast Lipid Synthesis
Kwiatek J. M., Gutierrez B., Izgu E. C., Han G-S., Carman G. M.
Journal of Lipid Research 2022, 63, 100282. (Link)
15.
MicroRNA Detection in Biologically Relevant Media Using a Split Aptamer Platform
Wang L., Hast K., Aggarwal T., Baci M., Hong J., Izgu E. C.*
Bioorganic & Medicinal Chemistry 2022, 69, 116909. (Link)
Special issue honoring Neal Devaraj: Chemical Tools for Interrogating Biological Processes
bioRxiv 2022
14.
Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign
Aggarwal T., Hansen A. W., Hong J., Ganguly A., York D. M., Khare S. D.*, Izgu E. C.*
ACS Chemical Biology 2022, 17, 1924–1936.
bioRxiv 2021
13.
Catecholamine-Copper Redox as a Basis for Site-Specific Single-Step Functionalization of Material Surfaces
Jia Z., Hast K., Izgu E. C.*
ACS Applied Materials & Interfaces 2021, 13, 4711–4722. (Link)
12.
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression
Yildirim O., Izgu E. C., Damle M., Chalei V., Ji F., Sadreyev R. I., Szostak J. W., Kingston R. E.
Cell Reports 2020, 31, 107629. (Link)
LincRNAs have a key role in regulating S-phase progression, which impacts cell cycle, chromosome organization, gene expression, protein localization, and intracellular transport.
Publications from Undergraduate, Doctoral, and Postdoctoral Research
11.
DNA Polymerase Activity on Synthetic N3′→P5′ Phosphoramidate DNA Templates
Lelyveld V. S., O’Flaherty D. K., Zhou L., Izgu E. C., Szostak J. W.
Nucleic Acids Research 2019, 47, 8941–8949. (Link)
NP-DNA
RNA
NP-DNA
RNA
10.
Enhanced Nonenzymatic RNA Copying with
2-Aminoimidazole-Activated Nucleotides
Li L., Prywes N., Tam C. P., O’Flaherty D. K., Lelyveld V. S., Izgu E. C., Pal A., Szostak J. W.
Journal of the American Chemical Society 2017, 139, 1810–1813. (Link)
9.
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes
Tam C. P., Fahrenbach A. C., Björkbom A., Prywes N., Izgu E. C., Szostak J. W.
Journal of the American Chemical Society 2017, 139, 571–574. (Link)
8.
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane
Izgu E. C., Björkbom A., Kamat N. P., Lelyveld V. S., Zhang, W., Jia T. Z., Szostak J. W.
Journal of the American Chemical Society 2016, 138, 16669–16676. (Link)
7.
Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Non-enzymatic Copying of Nucleic Acid Templates
Izgu E. C., Oh S. S., Szostak J. W.
Chemical Communications 2016, 52, 3684–3686. (Link)
6.
Uncovering the Thermodynamics of Monomer Binding for RNA Replication
Izgu E. C.,§ Fahrenbach A. C.,§ Zhang N., Li L., Zhang W.; Blain C., Larsen A. T., Szostak J. W.
Journal of the American Chemical Society 2015, 137, 6373–6382. (Link)
5.
Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group
Izgu E. C., Hoye T. R.
Chemical Science 2013, 4, 2262–2266. (Link)
Highlighted by Ebner, C. & Carreira, E. M. Synfacts 2013, 9, 0589.
4.
o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the 2-Aminophenyl Substituent
Izgu E. C., Hoye T. R.
Tetrahedron Letters 2012, 53, 4938–4941. (Link)
3.
Access to Functionalized Steroid Side Chains via Modified Julia Olefination
Izgu E. C., Burns A. C., Hoye T. R.
Organic Letters 2011, 13, 703–705. (Link)
2.
Long-range Shielding Effects in the H NMR Spectra of Mosher-like Ester Derivatives
1
Hoye T. R., Erickson S. E., Erickson-Birkedahl S. L., Hale C. R. H., Izgu E. C., Mayer M. J., Notz P. K., Renner M. K.
Organic Letters 2010, 12, 1768–1771. (Link)
1.
Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands
Bulut A., Aslan A., Izgu E. C., Dogan O.
Tetrahedron: Asymmetry 2007, 18, 1013–1016. (Link)
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