Phosphatidic Acid Mediates the Nem1-Spo7/Pah1 Phosphatase Cascade in Yeast Lipid Synthesis

Kwiatek, J. M., Gutierrez, B., Izgu, E. C., Han, G-S., Carman, G. M.

Journal Lipid Research  2022, 63, 100282. (link)

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Activity-Based Imaging of Lipid Environments Targeted by Peroxynitrite in Biomimetic Vesicles and Live Cells

Gutierrez, B., Erguven, H., Stone, M. R. L., Aggarwal, T., Izgu, E. C.*

bioRxiv  2022, doi: 10.1101/2022.06.22.497268

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Giant vesicle


Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules

Hast, K., Stone, M. R. L., Jia, Z., Baci, M., Aggarwal, T., Izgu, E. C.*

bioRxiv  2022, doi: 10.1101/2021.10.01.462811



MicroRNA Detection in Biologically Relevant Media Using a Split Aptamer Platform

Wang, L., Hast, K., Aggarwal, T., Baci, M., Hong, J., Izgu, E. C.*

Bioorganic & Medicinal Chemistry  2022, 69, 116909. (Link)  |  bioRxiv  2022, doi: 10.1101/2022.01.17.476684

Special issue honoring Neal Devaraj: Chemical Tools for Interrogating Biological Processes

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Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign

Aggarwal, T., Hansen, A. W., Hong, J., Ganguly, A., York, D. M., Khare, S. D.*, Izgu, E. C.*

ACS Chemical Biology  2022, 17, 1924–1936. (Link)  |  bioRxiv 2021, doi: 10.1101/2021.12.28.474375

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Catecholamine-Copper Redox as a Basis for Site-Specific Single-Step Functionalization of Material Surfaces

Jia, Z., Hast, K., Izgu, E. C.*

ACS Applied Materials & Interfaces  2021, 13, 4711–4722. (Link)

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S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression

Yildirim, O., Izgu, E. C., Damle, M., Chalei, V., Ji, F., Sadreyev, R. I., Szostak, J. W., Kingston, R. E.

Cell Reports  2020, 31, 107629. (Link)

Ozlem paper_Figure 1A_version 4_website_

WT RPE1 cells

Early S phase block: Impact on chromosome organization, cell cycle, and nuclear division.

S phase retardation: Impact on gene expression, protein localization, and intracellular transport.

Publications Prior to Research as Principal Investigator


DNA Polymerase Activity on Synthetic N3′→P5′ Phosphoramidate DNA Templates

Lelyveld, V. S., O’Flaherty, D. K., Zhou, L., Izgu, E. C., Szostak, J. W.

Nucleic Acids Research  2019, 47, 8941–8949. (Link)

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Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole-Activated Nucleotides

Li, L., Prywes, N., Tam, C. P., O’Flaherty, D. K., Lelyveld, V. S., Izgu, E. C., Pal, A., Szostak, J. W.

Journal of the American Chemical Society  2017, 139, 1810–1813. (Link)



Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes

Tam, C. P., Fahrenbach, A. C., Björkbom, A., Prywes, N., Izgu, E. C., Szostak, J. W.

Journal of the American Chemical Society  2017, 139, 571–574. (Link)

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N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane

Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z., Szostak, J. W.

Journal of the American Chemical Society  2016, 138, 16669–16676. (Link)


Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Nonenzymatic Copying of Nucleic Acid Templates

Izgu, E. C., Oh, S. S., Szostak, J. W.

Chemical Communications  2016, 52, 3684–3686. (Link)


Uncovering the Thermodynamics of Monomer Binding for RNA Replication

Izgu, E. C.,* Fahrenbach, A. C.,* Zhang, N., Li L., Zhang, W.; Blain, C., Larsen, A. T., Szostak, J. W.

Journal of the American Chemical Society  2015, 137, 6373–6382. (Link)


Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group

Izgu, E. C., Hoye, T. R.

Chemical Science  2013, 4, 2262–2266. (Link)

  • Highlighted by Ebner, C. & Carreira, E. M. in Synfacts  2013, 9, 0589.

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o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the

2-Aminophenyl Substituent

Izgu, E. C., Hoye, T. R.

Tetrahedron Letters  2012, 53, 4938–4941. (Link)



Access to Functionalized Steroid Side Chains via Modified Julia Olefination

Izgu, E. C., Burns, A. C., Hoye, T. R.

Organic Letters  2011, 13, 703–705. (Link)



Long-range Shielding Effects in the   H NMR Spectra of Mosher-like Ester Derivatives

Hoye, T. R., Erickson, S. E., Erickson-Birkedahl, S. L., Hale, C. R. H., Izgu, E. C., Mayer, M. J., Notz, P. K., Renner, M. K.

Organic Letters  2010, 12, 1768–1771. (Link)


Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands

Bulut, A., Aslan, A., Izgu, E. C., Dogan, O.

Tetrahedron: Asymmetry  2007, 18, 1013–1016. (Link)

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