17.
Activity-Based Imaging of Lipid Environments Targeted by Peroxynitrite in Biomimetic Vesicles and Live Cells
Gutierrez, B., Erguven, H., Stone, M. R. L., Aggarwal, T., and Izgu, E. C.*
bioRxiv 2022, doi: 10.1101/2022.06.22.497268
Giant vesicle
16.
Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules
Hast, K., Stone, M. R. L., Jia, Z., Baci, M., Aggarwal, T., and Izgu, E. C.*
bioRxiv 2022, doi: 10.1101/2021.10.01.462811
15.
MicroRNA Detection in Biologically Relevant Media Using a Split Aptamer Platform
Wang, L., Hast, K., Aggarwal, T., Baci, M., Hong, J., and Izgu, E. C.*
Bioorg. Med. Chem. 2022, 69, 116909. (Link) | bioRxiv 2022, doi: 10.1101/2022.01.17.476684
Special issue honoring Neal Devaraj: Chemical Tools for Interrogating Biological Processes
14.
Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign
Aggarwal, T., Hansen, A. W., Hong, J., Ganguly, A., York, D. M., Khare, S. D.*, and Izgu, E. C.*
ACS Chem. Biol. 2022 (Link) | bioRxiv 2021, doi: 10.1101/2021.12.28.474375
13.
Catecholamine-Copper Redox as a Basis for Site-Specific Single-Step Functionalization of Material Surfaces
Jia, Z., Hast, K., and Izgu, E. C.*
ACS Appl. Mater. Interfaces 2021, 13, 4711–4722. (Link)
12.
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression
Yildirim, O., Izgu, E. C., Damle, M., Chalei, V., Ji, F., Sadreyev, R. I., Szostak, J. W., and Kingston, R. E.
Cell Reports 2020, 31, 107629. (Link)
WT RPE1 cells
Early S phase block: Impact on chromosome organization, cell cycle, and nuclear division.
S phase retardation: Impact on gene expression, protein localization, and intracellular transport.
Publications Prior to Research as Principal Investigator
11.
DNA Polymerase Activity on Synthetic N3′→P5′ Phosphoramidate DNA Templates
Lelyveld, V. S., O’Flaherty, D. K., Zhou, L., Izgu, E. C., and Szostak, J. W.
Nucleic Acids Res. 2019, 47, 8941–8949. (Link)
10.
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole-Activated Nucleotides
Li, L., Prywes, N., Tam, C. P., O’Flaherty, D. K., Lelyveld, V. S., Izgu, E. C., Pal, A., and Szostak, J. W.
J. Am. Chem. Soc. 2017, 139, 1810–1813. (Link)
9.
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes
Tam, C. P., Fahrenbach, A. C., Björkbom, A., Prywes, N., Izgu, E. C., and Szostak, J. W.
J. Am. Chem. Soc. 2017, 139, 571–574. (Link)
8.
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane
Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z., and Szostak, J. W.
J. Am. Chem. Soc. 2016, 138, 16669–16676. (Link)
7.
Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Nonenzymatic Copying of Nucleic Acid Templates
Izgu, E. C., Oh, S. S. and Szostak, J. W.
Chem. Commun. 2016, 52, 3684–3686. (Link)
6.
Uncovering the Thermodynamics of Monomer Binding for RNA Replication
Izgu, E. C.,* Fahrenbach, A. C.,* Zhang, N., Li L., Zhang, W.; Blain, C., Larsen, A. T., and Szostak, J. W.
J. Am. Chem. Soc. 2015, 137, 6373–6382. (Link)
-
Highlighted by Ebner, C. & Carreira, E. M. in Synfacts 2013, 9, 0589.
5.
Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group
Izgu, E. C. and Hoye, T. R.
Chem. Sci. 2013, 4, 2262–2266. (Link)
4.
o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the
2-Aminophenyl Substituent
Izgu, E. C. and Hoye, T. R.
Tetrahedron Lett. 2012, 53, 4938–4941. (Link)
3.
Access to Functionalized Steroid Side Chains via Modified Julia Olefination
Izgu, E. C., Burns, A. C., and Hoye, T. R.
Org. Lett. 2011, 13, 703–705. (Link)
2.
1
Long-range Shielding Effects in the H NMR Spectra of Mosher-like Ester Derivatives
Hoye, T. R., Erickson, S. E., Erickson-Birkedahl, S. L., Hale, C. R. H., Izgu, E. C., Mayer, M. J., Notz, P. K., and Renner, M. K.
Org. Lett. 2010, 12, 1768–1771. (Link)
1.
Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands
Bulut, A., Aslan, A., Izgu, E. C., and Dogan, O.
Tetrahedron: Asymm. 2007, 18, 1013–1016. (Link)
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