14.

Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules.

Hast, K., Jia, Z., Baci, M., Aggarwal, T., and Izgu, E. C.*

bioRxiv  2021, doi: 10.1101/2021.10.01.462811

13.

Catecholamine-Copper Redox as a Basis for Site-Specific Single-Step Functionalization of Material Surfaces.

Jia, Z., Hast, K., and Izgu, E. C.*

ACS Appl. Mater. Interfaces  2021, 13, 4711–4722. (Link)

Drop coating_png300_website.png

12.

S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression.

Yildirim, O., Izgu, E. C., Damle, M., Chalei, V., Ji, F., Sadreyev, R. I., Szostak, J. W., and Kingston, R. E.

Cell Reports  2020, 31, 107629. (Link)

Ozlem paper_Figure 1A_version 4_website_

WT RPE1 cells

Early S phase block: Impact on chromosome organization, cell cycle, and nuclear division.

S phase retardation: 

Impact on gene expression, protein localization, and intracellular transport.

Publications Prior to Research as Principal Investigator

11.

DNA Polymerase Activity on Synthetic N3′→P5′ Phosphoramidate DNA Templates.

Lelyveld, V. S., O’Flaherty, D. K., Zhou, L., Izgu, E. C., and Szostak, J. W.

Nucleic Acids Res. 2019, 47, 8941–8949. (Link)

Website - NP-DNA vs RNA.png
NP-DNA vs RNA crystal structures.png

10.

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole-Activated Nucleotides.

Li, L., Prywes, N., Tam, C. P., O’Flaherty, D. K., Lelyveld, V. S., Izgu, E. C., Pal, A., and Szostak, J. W.

J. Am. Chem. Soc. 2017, 139, 1810–1813. (Link)

2-AI_TOC_IzguLab.png

9.

Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes.

Tam, C. P., Fahrenbach, A. C., Björkbom, A., Prywes, N., Izgu, E. C., and Szostak, J. W.

J. Am. Chem. Soc. 2017, 139, 571–574. (Link)

Downstream Oligo binding_TOC_IzguLab.png

8.

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane.

Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z., and Szostak, J. W.

J. Am. Chem. Soc. 2016, 138, 16669–16676. (Link)

7.

Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Nonenzymatic Copying of Nucleic Acid Templates.

Izgu, E. C., Oh, S. S. and Szostak, J. W.

Chem. Commun. 2016, 52, 3684–3686. (Link)

6.

Uncovering the Thermodynamics of Monomer Binding for RNA Replication.

Izgu, E. C.,* Fahrenbach, A. C.,* Zhang, N., Li L., Zhang, W.; Blain, C., Larsen, A. T., and Szostak, J. W.

J. Am. Chem. Soc. 2015, 137, 6373–6382. (Link)

Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group.

Izgu, E. C. and Hoye, T. R.

Chem. Sci. 2013, 4, 2262–2266. (Link)​​​

  • Highlighted by Ebner, C. & Carreira, E. M. in Synfacts 2013, 9, 0589.

5.

Leuconolam_ChemSci_TOC modified_2nd.png

o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the 2-Aminophenyl Substituent.

Izgu, E. C. and Hoye, T. R.

Tetrahedron Lett. 2012, 53, 4938–4941. (Link)

4.

AnilinoStannane_TetLett_TOC.png

Access to Functionalized Steroid Side Chains via Modified Julia Olefination.

Izgu, E. C., Burns, A. C., and Hoye, T. R.

Org. Lett. 2011, 13, 703–705. (Link)

3.

1

Long-range Shielding Effects in the   H NMR Spectra of Mosher-like Ester Derivatives.

Hoye, T. R., Erickson, S. E., Erickson-Birkedahl, S. L., Hale, C. R. H., Izgu, E. C., Mayer, M. J., Notz, P. K., and Renner, M. K.

Org. Lett. 2010, 12, 1768–1771. (Link)

2.

1.

Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands.

Bulut, A., Aslan, A., Izgu, E. C., and Dogan, O.

Tetrahedron: Asymm. 2007, 18, 1013–1016. (Link)

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