27.
Therapeutic Targeting of cGAS–STING in Epithelial Inflammation
Tadros N, Oztas Y.*, Izgu E. C.*
Trends in Pharmacological Sciences
(invited)
26.
Lipidation as a Driver of Spatial Organization and Function in Proteins and Nucleic Acids
Zhang H., Izgu E. C.*
ACS Chemical Biology
2026 (in press)
25.
cGAS-STING Pathway in Lung Cancer and Emerging Therapeutic Approaches
Joshi A., Izgu E. C.*
24.
Imaging Oxidative and Nitrative Stress in Membranes
Wang L.,§, Izgu E. C.§*
(§ Equal contribution)
Methods in Enzymology
2026, 726, 114–142 (Link)
Lipids and Membranes: Detection by Imaging and Lipidomics
23.
A Small-Molecule Approach Enables RNA Aptamers to Function as Sensors for Reactive Inorganic Targets
Aggarwal T.,§ Wang L.,§ Gutierrez B., Guven H., Erguven H., Cho S., Izgu E. C.*
Angewandte Chemie International Edition
2025, 64, e202421936 (Link), Designated as Hot Paper
Top 10% most-read article
Highlighted in Chemistry & Engineering News (C&EN)
Highlighted in EurekAlert!
22.
Benzylic Trifluoromethyl Accelerates 1,6-Elimination Toward Rapid Probe Activation
Wang L., Sivakumar A., Zhang R.,§ Cho S.,§
Aggarwal T., Kim Y., Wang L., Izgu E. C.*
(§ Equal contribution)
bioRxiv
2024 (Link)
21.
Protocol for Detecting Nitrative Stress in Biological Lipid Membranes in Murine Cells and Tissues
Aggarwal T., Bellomo A.,§ Stevenson E. R.,§
Herbert J., Laskin D. L., Gow A. J., Izgu E. C.*
(§ Equal contribution)
STAR Protocols
2024, 5, 103268 (Link)
20.
Protocol for Building Synthetic Protocell Membranes that Sense Redox Using Synthetic Phospholipids and Natural Lipids
Wang L.,§ Dresel M. J.,§ Robinson M., Izgu E. C.*
(§ Equal contribution)
STAR Protocols
2024, 5, 103169 (Link)
19.
Biomimetic Vesicles with Designer Phospholipids Can Sense Environmental Redox Cues
Erguven H.,§ Wang L.,§ Gutierrez B., Beaven A. H., Sodt A. J., Izgu E. C.*
(§ Equal contribution)
JACS Au
2024, 4, 1841–1853. (Link)
ChemRxiv 2023
18.
Direct Assessment of Nitrative Stress in Lipid Environments: Applications of a Designer Lipid-Based Biosensor for Peroxynitrite
Gutierrez B.,§ Aggarwal T.,§ Erguven H., Stone M. R. L., Guo C., Bellomo A., Abramova E., Stevenson E., Laskin D. L., Gow A. J., Izgu E. C.*
(§ Equal contribution)
iScience
2023, 26, 108567. (Link)
17.
Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules
Hast K., Stone M. R. L., Jia Z., Baci M., Aggarwal T., Izgu E. C.*
ACS Applied Materials & Interfaces
2023,15, 4996–5009. (Link)
bioRxiv 2022
16.
Phosphatidic Acid Mediates the Nem1-Spo7/Pah1 Phosphatase Cascade in Yeast Lipid Synthesis
Kwiatek J. M., Gutierrez B., Izgu E. C., Han G-S., Carman G. M.
Journal of Lipid Research
2022, 63, 100282. (Link)
15.
MicroRNA Detection in Biologically Relevant Media Using a Split Aptamer Platform
Wang L., Hast K., Aggarwal T., Baci M., Hong J., Izgu E. C.*
Bioorganic & Medicinal Chemistry
2022, 69, 116909. (Link)
Special issue honoring Neal Devaraj: Chemical Tools for Interrogating Biological Processes
bioRxiv 2022
14.
Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign
Aggarwal T., Hansen A. W., Hong J., Ganguly A., York D. M., Khare S. D.*, Izgu E. C.*
ACS Chemical Biology
2022, 17, 1924–1936. (Link)
bioRxiv 2021
13.
Catecholamine-Copper Redox as a Basis for Site-Specific Single-Step Functionalization of Material Surfaces
Jia Z., Hast K., Izgu E. C.*
ACS Applied Materials & Interfaces
2021, 13, 4711–4722. (Link)
12.
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression
Yildirim O., Izgu E. C., Damle M., Chalei V., Ji F., Sadreyev R. I., Szostak J. W., Kingston R. E.
Cell Reports
2020, 31, 107629. (Link)
Long intergenic non-coding RNAs play important roles in regulating S-phase progression, thereby influencing cell cycle, chromatin organization, gene expression, protein localization, and intracellular transport.
Publications from Undergraduate, Doctoral, and Postdoctoral Research
11.
DNA Polymerase Activity on Synthetic N3′→P5′ Phosphoramidate DNA Templates
Lelyveld V. S., O’Flaherty D. K., Zhou L., Izgu E. C., Szostak J. W.
Nucleic Acids Research
2019, 47, 8941–8949. (Link)
NP-DNA
RNA
NP-DNA
RNA
10.
Enhanced Nonenzymatic RNA Copying with
2-Aminoimidazole-Activated Nucleotides
Li L., Prywes N., Tam C. P., O’Flaherty D. K., Lelyveld V. S., Izgu E. C., Pal A., Szostak J. W.
Journal of the American Chemical Society
2017, 139, 1810–1813. (Link)
9.
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes
Tam C. P., Fahrenbach A. C., Björkbom A., Prywes N., Izgu E. C., Szostak J. W.
Journal of the American Chemical Society
2017, 139, 571–574. (Link)
8.
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane
Izgu E. C., Björkbom A., Kamat N. P., Lelyveld V. S., Zhang, W., Jia T. Z., Szostak J. W.
Journal of the American Chemical Society
2016, 138, 16669–16676. (Link)
7.
Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Non-enzymatic Copying of Nucleic Acid Templates
Izgu E. C., Oh S. S., Szostak J. W.
Chemical Communications
2016, 52, 3684–3686. (Link)
6.
Uncovering the Thermodynamics of Monomer Binding for RNA Replication
Izgu E. C.,§ Fahrenbach A. C.,§ Zhang N., Li L., Zhang W.; Blain C., Larsen A. T., Szostak J. W.
Journal of the American Chemical Society 2015, 137, 6373–6382. (Link)
5.
Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group
Izgu E. C., Hoye T. R.
Chemical Science
2013, 4, 2262–2266. (Link)
Highlighted by Ebner, C. & Carreira, E. M. Synfacts 2013, 9, 0589.
4.
o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the 2-Aminophenyl Substituent
Izgu E. C., Hoye T. R.
Tetrahedron Letters
2012, 53, 4938–4941. (Link)
3.
Access to Functionalized Steroid Side Chains via Modified Julia Olefination
Izgu E. C., Burns A. C., Hoye T. R.
Organic Letters
2011, 13, 703–705. (Link)
2.
Long-range Shielding Effects in the H NMR Spectra of Mosher-like Ester Derivatives
1
Hoye T. R., Erickson S. E., Erickson-Birkedahl S. L., Hale C. R. H., Izgu E. C., Mayer M. J., Notz P. K., Renner M. K.
Organic Letters
2010, 12, 1768–1771. (Link)
1.
Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands
Bulut A., Aslan A., Izgu E. C., Dogan O.
Tetrahedron: Asymmetry
2007, 18, 1013–1016. (Link)
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