17.

Activity-Based Imaging of Lipid Environments Targeted by Peroxynitrite in Biomimetic Vesicles and Live Cells

Gutierrez, B., Erguven, H., Stone, M. R. L., Aggarwal, T., and Izgu, E. C.*

bioRxiv 2022, doi: 10.1101/2022.06.22.497268

RNS Lipid project_GV light-up cartoon_v4.png
RNS lipid liposomal delivery figure.png

Giant vesicle

16.

Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules

Hast, K., Stone, M. R. L., Jia, Z., Baci, M., Aggarwal, T., and Izgu, E. C.*

bioRxiv 2022, doi: 10.1101/2021.10.01.462811

DOPA-Tet_TCO_v2_web.png

15.

MicroRNA Detection in Biologically Relevant Media Using a Split Aptamer Platform

Wang, L., Hast, K., Aggarwal, T., Baci, M., Hong, J., and Izgu, E. C.*

Bioorg. Med. Chem. 2022, 69, 116909. (Link)  |  bioRxiv 2022, doi: 10.1101/2022.01.17.476684

Special issue honoring Neal Devaraj: Chemical Tools for Interrogating Biological Processes

miRNA detection BMC_highlight website_v.png

14.

Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign

Aggarwal, T., Hansen, A. W., Hong, J., Ganguly, A., York, D. M., Khare, S. D.*, and Izgu, E. C.*

ACS Chem. Biol. 2022 (Link)  |  bioRxiv 2021, doi: 10.1101/2021.12.28.474375

9N_NP-DNA_TOC updated copy.png

13.

Catecholamine-Copper Redox as a Basis for Site-Specific Single-Step Functionalization of Material Surfaces

Jia, Z., Hast, K., and Izgu, E. C.*

ACS Appl. Mater. Interfaces  2021, 13, 4711–4722. (Link)

Drop coating_png300_website.png

12.

S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression

Yildirim, O., Izgu, E. C., Damle, M., Chalei, V., Ji, F., Sadreyev, R. I., Szostak, J. W., and Kingston, R. E.

Cell Reports  2020, 31, 107629. (Link)

Ozlem paper_Figure 1A_version 4_website_

WT RPE1 cells

Early S phase block: Impact on chromosome organization, cell cycle, and nuclear division.

S phase retardation: Impact on gene expression, protein localization, and intracellular transport.

Publications Prior to Research as Principal Investigator

11.

DNA Polymerase Activity on Synthetic N3′→P5′ Phosphoramidate DNA Templates

Lelyveld, V. S., O’Flaherty, D. K., Zhou, L., Izgu, E. C., and Szostak, J. W.

Nucleic Acids Res.  2019, 47, 8941–8949. (Link)

Website - NP-DNA vs RNA.png
NP-DNA vs RNA crystal structures.png

10.

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole-Activated Nucleotides

Li, L., Prywes, N., Tam, C. P., O’Flaherty, D. K., Lelyveld, V. S., Izgu, E. C., Pal, A., and Szostak, J. W.

J. Am. Chem. Soc.  2017, 139, 1810–1813. (Link)

2-AI_TOC_IzguLab.png

9.

Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes

Tam, C. P., Fahrenbach, A. C., Björkbom, A., Prywes, N., Izgu, E. C., and Szostak, J. W.

J. Am. Chem. Soc.  2017, 139, 571–574. (Link)

Downstream Oligo binding_TOC_IzguLab.png

8.

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane

Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z., and Szostak, J. W.

J. Am. Chem. Soc.  2016, 138, 16669–16676. (Link)

7.

Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Nonenzymatic Copying of Nucleic Acid Templates

Izgu, E. C., Oh, S. S. and Szostak, J. W.

Chem. Commun.  2016, 52, 3684–3686. (Link)

6.

Uncovering the Thermodynamics of Monomer Binding for RNA Replication

Izgu, E. C.,* Fahrenbach, A. C.,* Zhang, N., Li L., Zhang, W.; Blain, C., Larsen, A. T., and Szostak, J. W.

J. Am. Chem. Soc.  2015, 137, 6373–6382. (Link)

  • Highlighted by Ebner, C. & Carreira, E. M. in Synfacts  2013, 9, 0589.

5.

Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group

Izgu, E. C. and Hoye, T. R.

Chem. Sci.  2013, 4, 2262–2266. (Link)

Leuconolam_ChemSci_TOC modified_2nd.png

4.

o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the

2-Aminophenyl Substituent

Izgu, E. C. and Hoye, T. R.

Tetrahedron Lett.  2012, 53, 4938–4941. (Link)

AnilinoStannane_TetLett_TOC.png

3.

Access to Functionalized Steroid Side Chains via Modified Julia Olefination

Izgu, E. C., Burns, A. C., and Hoye, T. R.

Org. Lett.  2011, 13, 703–705. (Link)

2.

1

Long-range Shielding Effects in the   H NMR Spectra of Mosher-like Ester Derivatives

Hoye, T. R., Erickson, S. E., Erickson-Birkedahl, S. L., Hale, C. R. H., Izgu, E. C., Mayer, M. J., Notz, P. K., and Renner, M. K.

Org. Lett.  2010, 12, 1768–1771. (Link)

1.

Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands

Bulut, A., Aslan, A., Izgu, E. C., and Dogan, O.

Tetrahedron: Asymm.  2007, 18, 1013–1016. (Link)

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