Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules.

Hast, K., Jia, Z., Baci, M., Aggarwal, T., and Izgu, E. C.*

bioRxiv  2021, doi: 10.1101/2021.10.01.462811


Catecholamine-Copper Redox as a Basis for Site-Specific Single-Step Functionalization of Material Surfaces.

Jia, Z., Hast, K., and Izgu, E. C.*

ACS Appl. Mater. Interfaces  2021, 13, 4711–4722. (Link)

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S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression.

Yildirim, O., Izgu, E. C., Damle, M., Chalei, V., Ji, F., Sadreyev, R. I., Szostak, J. W., and Kingston, R. E.

Cell Reports  2020, 31, 107629. (Link)

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WT RPE1 cells

Early S phase block: Impact on chromosome organization, cell cycle, and nuclear division.

S phase retardation: 

Impact on gene expression, protein localization, and intracellular transport.

Publications Prior to Research as Principal Investigator


DNA Polymerase Activity on Synthetic N3′→P5′ Phosphoramidate DNA Templates.

Lelyveld, V. S., O’Flaherty, D. K., Zhou, L., Izgu, E. C., and Szostak, J. W.

Nucleic Acids Res. 2019, 47, 8941–8949. (Link)

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Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole-Activated Nucleotides.

Li, L., Prywes, N., Tam, C. P., O’Flaherty, D. K., Lelyveld, V. S., Izgu, E. C., Pal, A., and Szostak, J. W.

J. Am. Chem. Soc. 2017, 139, 1810–1813. (Link)



Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes.

Tam, C. P., Fahrenbach, A. C., Björkbom, A., Prywes, N., Izgu, E. C., and Szostak, J. W.

J. Am. Chem. Soc. 2017, 139, 571–574. (Link)

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N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane.

Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z., and Szostak, J. W.

J. Am. Chem. Soc. 2016, 138, 16669–16676. (Link)


Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Nonenzymatic Copying of Nucleic Acid Templates.

Izgu, E. C., Oh, S. S. and Szostak, J. W.

Chem. Commun. 2016, 52, 3684–3686. (Link)


Uncovering the Thermodynamics of Monomer Binding for RNA Replication.

Izgu, E. C.,* Fahrenbach, A. C.,* Zhang, N., Li L., Zhang, W.; Blain, C., Larsen, A. T., and Szostak, J. W.

J. Am. Chem. Soc. 2015, 137, 6373–6382. (Link)

Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group.

Izgu, E. C. and Hoye, T. R.

Chem. Sci. 2013, 4, 2262–2266. (Link)​​​

  • Highlighted by Ebner, C. & Carreira, E. M. in Synfacts 2013, 9, 0589.


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o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the 2-Aminophenyl Substituent.

Izgu, E. C. and Hoye, T. R.

Tetrahedron Lett. 2012, 53, 4938–4941. (Link)



Access to Functionalized Steroid Side Chains via Modified Julia Olefination.

Izgu, E. C., Burns, A. C., and Hoye, T. R.

Org. Lett. 2011, 13, 703–705. (Link)



Long-range Shielding Effects in the   H NMR Spectra of Mosher-like Ester Derivatives.

Hoye, T. R., Erickson, S. E., Erickson-Birkedahl, S. L., Hale, C. R. H., Izgu, E. C., Mayer, M. J., Notz, P. K., and Renner, M. K.

Org. Lett. 2010, 12, 1768–1771. (Link)



Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands.

Bulut, A., Aslan, A., Izgu, E. C., and Dogan, O.

Tetrahedron: Asymm. 2007, 18, 1013–1016. (Link)

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